On Sunday, September 14, 2025, the NFL staged 12 games that produced 75 total touchdowns. At Arrowhead Stadium, the Philadelphia Eagles defeated the Kansas City Chiefs 20–17 in a rematch of Super Bowl LIX. Jalen Hurts and Saquon Barkley each ran for touchdowns, and Andrew Mukuba intercepted Patrick Mahomes in the fourth quarter to turn the game. Philadelphia improved to 2-0, thus Kansas City fell to 0-2 for the first time since 2014.
The decisive play came with the Chiefs trailing 13–10 in the fourth quarter. Mahomes’ pass intended for Travis Kelce deflected into Mukuba’s hands at the Eagles’ six-yard line. Mukuba returned the ball 41 yards before rookie tackle Josh Simmons stopped him short of the end zone. “I threw it a tad too early,” Mahomes told reporters. “If I could put it on his body, he can catch it, take the hit and get into the end zone.”
Philadelphia extended the drive with a 28-yard completion from Hurts to DeVonta Smith. The Eagles relied on their rushing attack and the “tush push” sneak to close the game. Chiefs head coach Andy Reid said afterward, “You try to get penetration is what you try to do. Might have had a couple of them (where) they got off a little early on, but we’ll look at that.” Defensive tackle Chris Jones added, “Sometimes you can’t get all the calls right… We think (Eagles offensive linemen) jumped multiple times. So the official didn’t see it, we just gotta play the next down.”
Sportsbooks adjusted their markets after the result. Philadelphia held steady as a top Super Bowl contender at +650 to +700 across major operators, with a season win total of 11.5. Kansas City’s futures lengthened from preseason levels of +750 to +1200 or longer, with division odds listed at +230 and playoff qualification at -165. Mahomes said he threw his intercepted pass too early, Reid noted he would review the tush-push snaps, and Chris Jones said the team had to play through missed calls.
In Arlington, Texas, the Dallas Cowboys beat the New York Giants 40–37 in overtime. The final 12 minutes of regulation featured five go-ahead touchdowns between Dak Prescott and Russell Wilson. Prescott found George Pickens from six yards with 52 seconds left before Wilson hit Malik Nabors from 48 yards for a 37–34 New York lead. Brandon Aubrey tied the game with a 64-yard field goal and won it with a 46-yarder in overtime.
Cincinnati defeated Jacksonville 31–27, but lost quarterback Joe Burrow to a toe injury in the first half. Burrow left on crutches with a boot on his left foot and did not speak afterward. Backup Jake Browning threw for 241 yards and completed a 15-play, 92-yard drive capped by his one-yard sneak with 18 seconds remaining. The Bengals started 2-0 for the first time since 2018.
Reports later confirmed Burrow had strained toe ligaments and would miss several weeks, with surgery possibly extending his absence to three months. Sportsbooks quickly moved Cincinnati’s futures from +2000 preseason to +2500 after Week 1, then +3500, and now +4500 to +5000, with some at +8000. Burrow’s MVP odds were taken off the boards entirely. Week 3 lines reopened with Cincinnati listed as underdogs behind Browning.
In Pittsburgh, the Seattle Seahawks beat the Steelers 31–17. Jason Myers put Seattle ahead with a 54-yard field goal early in the fourth quarter. On the kickoff, the ball skipped past rookie Kaleb Johnson, and George Holani recovered it in the end zone for a touchdown. Sam Darnold threw two touchdowns, and Aaron Rodgers went 18 of 33 for 203 yards with one score and two interceptions.
The Indianapolis Colts edged the Denver Broncos 29–28 at Lucas Oil Stadium. Rookie kicker Spencer Shrader missed a 60-yard attempt with three seconds left, but Denver’s Dondrea Tillman was flagged for leverage. The penalty advanced the ball 15 yards, and Shrader converted from 45 yards to win. Indianapolis improved to 2-0 for the first time since 2009.
In Glendale, the Arizona Cardinals held off the Carolina Panthers 27–22. Arizona led 27–3 before Bryce Young led a furious comeback with three touchdown passes. His final score to Harvey Renfrow cut the deficit to five with 1:58 remaining, and Carolina recovered the onside kick. Calais Campbell ended the rally with a sack on fourth down at the two-minute mark.
The Detroit Lions overpowered the Chicago Bears 52–21 at Soldier Field. Jared Goff threw for 334 yards and tied a career high with five touchdown passes. Three of those went to Amon-Ra St. Brown as Detroit capitalized on two first-half turnovers. The Lions built a 28–14 halftime lead and cruised to victory.
At MetLife Stadium, the Buffalo Bills defeated the New York Jets 30–10. Josh Allen briefly left after suffering a bloody nose but returned to throw two touchdowns. James Cook ran for 132 yards and scored twice on the ground. Jets quarterback Justin Fields struggled before exiting with a concussion in the fourth quarter, replaced by Tyrod Taylor, who threw a late touchdown.
The New England Patriots earned a 33–27 win over the Miami Dolphins at Hard Rock Stadium, marking Mike Vrabel’s first win as head coach. Rookie quarterback Drake Maye went 19 of 23 for 230 yards with two passing touchdowns and one rushing score. Antonio Gibson returned a kickoff 90 yards for the decisive touchdown immediately after Miami’s Malik Washington had run back a punt 74 yards for the lead.
The San Francisco 49ers beat the New Orleans Saints 26–21 at Caesars Superdome. With Brock Purdy unavailable, Mac Jones started and threw three touchdowns while completing 26 of 39 passes for 279 yards. Saints quarterback Spencer Rattler matched him with three touchdown passes and went 25 of 34 for 206 yards. Alvin Kamara rushed 21 times for 100 yards in the loss.
The Baltimore Ravens defeated the Cleveland Browns 41–17 at M&T Bank Stadium. Lamar Jackson threw four touchdown passes. Browns quarterback Joe Flacco, returning to Baltimore as an opponent, completed 25 of 45 passes for 199 yards with one touchdown, an interception, and a lost fumble. Cleveland was held to 17 points after scoring 24 the week before.
The Los Angeles Rams beat the Tennessee Titans 33–19 at SoFi Stadium. Matthew Stafford threw for 298 yards and two touchdowns, rookie wideout Puka Nacua added a 45-yard rushing score, and Davante Adams recorded 106 yards and a touchdown catch. Titans rookie quarterback Cam Ward was sacked five times, including two by Byron Young, who also forced a fumble.
At U.S. Bank Stadium, the Atlanta Falcons beat the Minnesota Vikings 22–6. Bijan Robinson rushed for 143 yards, and Tyler Allgeier added 67 yards and a touchdown on 13 carries. Parker Romo converted all five of his field goal attempts in his NFL debut. The Falcons’ defense sacked rookie quarterback JJ McCarthy six times and forced three turnovers.
